Expression of Different 17β-Hydroxysteroid Dehydrogenase Types and Their Activities in Human Prostate Cancer Cells*
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چکیده
منابع مشابه
Expression of different 17beta-hydroxysteroid dehydrogenase types and their activities in human prostate cancer cells.
The 17beta-hydroxysteroid dehydrogenase (17betaHSD) enzyme system governs important redox reactions at the C17 position of steroid hormones. Different 17betaHSD types (no. 1-4) have been identified to date in peripheral human tissues, such as placenta, testis, and breast. However, there is little information on their expression and activity in either normal or malignant prostate. In the present...
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The objective of the present study was to investigate the effects of genistein and equol on 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-hydroxysteroid dehydrogenase 3 (17β-HSD3) in human and rat testis microsomes. These enzymes (3β-HSD and 17β-HSD3), along with two others (cytochrome P450 side-chain cleavage enzyme and cytochrome P450 17α-hydroxylase/17-20 lyase), catalyze the reactions th...
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BACKGROUND Diabetes is characterized by chronic hyperglycemia, and hyperglycemia can increase reactive oxygen species (ROS) production from the mitochondrial electron transport chain. The formation of ROS in cells induces oxidative stress and activates oxidative damage-inducing genes. There is no research on the protein levels of oxidative damage-related genes AKR1C3 in human diabetic skin. We ...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 1997
ISSN: 0013-7227,1945-7170
DOI: 10.1210/endo.138.11.5497